Once upon a time, the founder of alchemy led people from a dying world to a new land.In this fertile and harmonious land where man-made "Gods of Creation" act as guardians, humans lead a peaceful existence.However, a long time has since passed, and the "Dust" of death began to engulf Arcaus.Gods gone mad become heinous "Gods of Misfortune" and begin to devour the world, and ash demons born of dust bare its fangs at the living.Like burnt pieces of paper and worm-eaten clothes, the world finds itself in an era where the earth was being eroded by the ashes.The people were not entirely unprepared, however.Alchemists who wished to carry on the miracles brought upon by its founder gather at the Cagliostro Academy, a school boasting the highest levels of wisdom.Among them is another—a young alchemist who knocks on the doors of the academy with aspirations in mind.

曾经为炼金术的创始人，带领人们从逐渐灭亡的世界至一片新大地。
作为人造的『创神』们守护者，在和谐丰腴的土地上，人们过着平静的生活。

然而，经过很长一段时间，死亡物质「尘灰」开始吞噬新天地──阿尔克斯大陆。
疯狂的创神化为『祸神』吞噬大地，而由尘灰生出的怪物『灰魔』则对活人撕牙裂嘴展开攻击。
像吃虫子，又像是烧焦的纸片般，大地被尘灰侵蚀的时代──。

但是，人们绝不是毫无办法。
继承创始人奇蹟的炼金术师们聚集在智慧的最高学府──卡里奥斯特罗魔导机关。

而这里有一个人，一名年轻的炼金术师胸怀大志与憧憬的敲了魔导机关的大门。

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「我要守护这美丽的和谐世界──」

「集合！睿智与调和之学徒！炼金术学园ＲＰＧ」

「对抗灭亡的宿命！炼金术师──！」